Brucellosis with mesangial IgA
ثبت نشده
چکیده
'Doll R, Gray R, Hafner B, Peto R. Mortality in relation to smoking: 22 years' observation in female British doctors. Br Med3J 1980;i:967-71. 2Hirayama T. Non-smoking wives of heavy smokers have a higher risk of lung cancer: a study in Japan, Br MedJ7 1981;282:183-5. 3Correa P, Pickle LW, Fontham E, Lin Y, Haenszel W. Passive smoking and lung cancer. Lancet 1983;ii:595-7. 4van der Heide RM. Resultaten van een geneeskundig onderzoek van 3091 gezonde mannen en vrouwen (with English summary: Results of a medical examination of 3091 healthymen and women, pp 128-30). Amsterdam: University of Amsterdam, 1959. PhD thesis. I Vandenbroucke JP, Matroos A, van der Heide-Wessel C, van der Heide RM. Parental survival, an independent predictor of mortality in middleaged persons. Am J Epidemiol 1984;119:742-50.
منابع مشابه
Brucellosis with nephrotic syndrome, nephritis and IgA nephropathy.
A patient with systemic brucellosis due to Brucella melitensis had severe renal involvement. Clinical features included hypertension, macroscopic haematuria, massive proteinuria of 10 g per 24 hours and azotaemia. Following treatment with antibiotics, the azotaemia resolved and proteinuria decreased to less than 0.5 g per 24 hours, but microscopic haematuria and hypertension persisted. Renal bi...
متن کاملDimeric and polymeric IgA, but not monomeric IgA, enhance the production of IL-6 by human renal mesangial cells
Depositions of IgA in the renal glomerular mesangial area are a hallmark of IgA nephropathy, and are thought to be crucial for the onset of inflammation processes in IgA nephropathy. In this report we show that human mesangial cells (MC) in vitro bind IgA and that binding of IgA enhances the production of IL-6 by MC. Furthermore we show that the size of IgA is crucial in its capability to enhan...
متن کاملMesangial cells from patients with IgA nephropathy have increased susceptibility to galactose-deficient IgA1
BACKGROUND IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, affecting close to a million people. Circulating galactose-deficient IgA (gd-IgA), present in patients with IgAN, form immune complex deposits in the glomerular mesangium causing local proliferation and matrix expansion. Intriguing though, individuals having gd-IgA deposits in the kidneys do not necessarily ha...
متن کاملBerger's disease without IgA deposits?
Dr. A. Sessa, Unità Operativa di Nefrologia e Dialisi, Ospedale di Vimercate, I-20059 Vimercate (Italy) Dear Sir, The accompanying micrograph shows a typical glom-erulonephritis with mesangial electrondense deposits. The kidney biopsy was performed in a 17-year-old girl presenting the clinical picture of Berger’s disease but without IgA mesangial deposits on immunofluorescent microscopy; light ...
متن کاملAbsence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells.
IgA nephropathy (IgAN) is characterized by raised serum IgA and predominant mesangial IgA deposits of polymeric nature. The expression of IgA receptor molecules in white blood cells and glomerular mesangial cells has recently attracted much attention in relation to the uptake of IgA by these cells. This study investigates the expression of IgA Fc receptor (Fc alphaR1 or CD89), asialoglycoprotei...
متن کاملTumor Necrosis Factor α from Peripheral Blood Mononuclear Cells of IgA Nephropathy and Mesangial Cell Proliferation
BACKGROUND To investigate the role of mononuclear cells and their products on rat mesangial cell proliferation, we evaluated the effect of peripheral blood mononuclear cells (PBMC) culture supernatant of patients with IgA nephropathy on rat mesangial cells 3[H]-thymidine uptake, and measured the concentration of cytokines in the supernatant to find out which cytokine in PBMC culture supernatant...
متن کامل